With a rapid increase in the volume of textual data on the Internet, extracting useful information through innovative text mining techniques has become crucial.In this context, terminology jargon in the literature related to text-mining creates ambiguity and has made it very difficult for researchers to ornament focus in a specific direction and br
Giant anal condyloma
A 61 years old male patient presented to the AE Department reporting bleeding during defecation, difficulty and low pain while walking and sitting.On physical examination we saw an exophytic Wood Sculpture cauliflower like, ulcerated tumor mass measuring 20 x 14 cm that covered the whole perineum and a similar satellite Plasma Cutters lesion 3 x 4
The DNMT3A PWWP domain is essential for the normal DNA methylation landscape in mouse somatic cells and oocytes.
DNA methylation at CG sites is important for gene regulation and embryonic development.In mouse oocytes, de novo CG methylation requires preceding transcription-coupled histone mark H3K36me3 and is mediated by a DNA methyltransferase DNMT3A.DNMT3A has a PWWP domain, which recognizes H3K36me2/3, and heterozygous mutations in this domain, including D
Hesperidin Interaction with HMG-CoA-Reductase Enzyme in Hypercholesterolemia: A Study in Silico
Abstract: Dyslipidemia is a degenerative disease occurred with increased levels of fat and cholesterol levels in blood.One of the proteins used as anti-cholesterol is an HMG-CoA-Reductase.Hesperidin in orange peel can reduce cholesterol levels by interacting with HMG-CoA-Reductase.To prove this, an medium Argentina cow leather in silico method was
An Adverse Outcome Pathway for food nanomaterial-induced intestinal barrier disruption
IntroductionThe ingestion of nanomaterials (NMs) may impair the intestinal barrier, but the underlying mechanisms remain evasive, and evidence has not been systematically gathered or produced.A mechanistic-based approach would be instrumental in assessing whether relevant NMs disrupt the intestinal barrier, thereby supporting the NM risk assessment